Analgesic Effects of the Cressa Cretica Extract on Induced Neuropathic Pain in Rats, and the Potential Role of Opioid Receptors

Background: Damages to the peripheral fibers of sensory nerve cells and central neurons cause neuropathic pain. Manifestations pain occur in various conditions, including diabetes mellitus, chemotherapy, as side effects some medications. Cressa cretica has long been used traditional medicine for control. This study was conducted determine role opioid receptors analgesic effect hydroalcoholic extract C. an experimental model Methods: The prepared, its total phenolic flavonoid contents were standardized. Painful neuropathy induced rats by Chronic Constriction Injury (CCI) sciatic nerve. To evaluate extract, animals orally given (300 mg/kg), gabapentin (70 mg/kg) or normal saline (4 mL/kg) on days 3, 7, 14, 21 after surgery, behavioral tests performed 45 minutes taking receptors, Naloxone (1 mg/kg, IP) treated with 30 then 15 minutes. Results: attenuates CCI rats. works acutely chronically, depending dosage duration use. Conclusion: reduces CCI-induced rats, Naloxone, receptor antagonist, inhibits this effect.